Proanthocyanidins and the risk of prostate cancer in Italy.
Identifieur interne : 000847 ( Main/Exploration ); précédent : 000846; suivant : 000848Proanthocyanidins and the risk of prostate cancer in Italy.
Auteurs : Delphine Praud [Italie] ; Maria Parpinel [Italie] ; Valentina Guercio [Italie] ; Cristina Bosetti [Italie] ; Diego Serraino [Italie] ; Gaetano Facchini [Italie] ; Maurizio Montella [Italie] ; Carlo La Vecchia [Italie] ; Marta Rossi [Italie]Source :
- Cancer causes & control : CCC [ 1573-7225 ] ; 2018.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Analyse multivariée, Antioxydants (administration et posologie), Facteurs de risque, Femelle, Grading des tumeurs, Humains, Indice de masse corporelle, Italie (épidémiologie), Modèles logistiques, Mâle, Odds ratio, Proanthocyanidines (administration et posologie), Ration calorique, Régime alimentaire, Sujet âgé, Tumeurs de la prostate (épidémiologie), Études cas-témoins.
- MESH :
- administration et posologie : Antioxydants, Proanthocyanidines.
- épidémiologie : Italie, Tumeurs de la prostate.
- Adulte d'âge moyen, Analyse multivariée, Facteurs de risque, Femelle, Grading des tumeurs, Humains, Indice de masse corporelle, Modèles logistiques, Mâle, Odds ratio, Ration calorique, Régime alimentaire, Sujet âgé, Études cas-témoins.
- Wicri :
- geographic : Italie.
English descriptors
- KwdEn :
- Aged, Antioxidants (administration & dosage), Body Mass Index, Case-Control Studies, Diet, Energy Intake, Female, Humans, Italy (epidemiology), Logistic Models, Male, Middle Aged, Multivariate Analysis, Neoplasm Grading, Odds Ratio, Proanthocyanidins (administration & dosage), Prostatic Neoplasms (epidemiology), Risk Factors.
- MESH :
- chemical , administration & dosage : Antioxidants, Proanthocyanidins.
- geographic , epidemiology : Italy.
- epidemiology : Prostatic Neoplasms.
- Aged, Body Mass Index, Case-Control Studies, Diet, Energy Intake, Female, Humans, Logistic Models, Male, Middle Aged, Multivariate Analysis, Neoplasm Grading, Odds Ratio, Risk Factors.
Abstract
Proanthocyanidins are polymers of monomeric unit flavan-3-ols with antioxidant, anti-inflammatory and free radical scavenging activities. We investigated the association between proanthocyanidin intake and prostate cancer risk through data that were collected between 1991 and 2002 in an Italian case-control study, including a total of 1,294 incident, histologically confirmed cases of prostate cancer and 1,451 controls admitted to hospital for acute, non-neoplastic, and non-hormone-related diseases. We estimated odds ratios (ORs) and their 95% confidence intervals (CIs) using multiple logistic regression models, and computed energy-adjusted proanthocyanidin intakes using the residual method. The ORs for the highest versus the lowest tertile were 0.80 (95% CI 0.83-1.00) for energy-adjusted monomers and dimers combined, 0.72 (95% CI 0.59-0.87) for polymers with ≥ 3 mers, and 0.72 (95% CI 0.59-0.88) for total proanthocyanidins. The inverse relation was stronger among cases with a Gleason score ≥ 7, with the ORs of 0.56 (95% CI 0.40-0.78) for monomers and dimers, 0.62 (95% CI 0.40-0.78) for polymers with ≥ 3 mers, and 0.57 (95% CI 0.42-0.77) for total proanthocyanidins. These risk estimates were consistent across strata of age, education, body mass index, and family history of prostate cancer. Our data indicate an inverse association between proanthocyanidins and prostate cancer risk.
DOI: 10.1007/s10552-018-1002-7
PubMed: 29350310
Affiliations:
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nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Parpinel, Maria" sort="Parpinel, Maria" uniqKey="Parpinel M" first="Maria" last="Parpinel">Maria Parpinel</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Hygiene and Epidemiology, Department of Medicine, University of udine, Udine, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Hygiene and Epidemiology, Department of Medicine, University of udine, Udine</wicri:regionArea><wicri:noRegion>Udine</wicri:noRegion></affiliation></author><author><name sortKey="Guercio, Valentina" sort="Guercio, Valentina" uniqKey="Guercio V" first="Valentina" last="Guercio">Valentina Guercio</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical Sciences and Community Health, 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Cancer Epidemiology, CRO Aviano National Cancer Institute, Via Franco Gallini 2, 33081, Aviano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Cancer Epidemiology, CRO Aviano National Cancer Institute, Via Franco Gallini 2, 33081, Aviano</wicri:regionArea><wicri:noRegion>Aviano</wicri:noRegion></affiliation></author><author><name sortKey="Facchini, Gaetano" sort="Facchini, Gaetano" uniqKey="Facchini G" first="Gaetano" last="Facchini">Gaetano Facchini</name><affiliation wicri:level="1"><nlm:affiliation>Departmental Unit of Experimental Uro-Andrological Clinical Oncology, Department of Uro-Gynaecological Oncology, National Cancer Institute - IRCCS- G. Pascale Foundation, Via M. Semmola, 80131, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Departmental Unit of Experimental Uro-Andrological Clinical Oncology, Department of Uro-Gynaecological Oncology, National Cancer Institute - IRCCS- G. Pascale Foundation, Via M. Semmola, 80131, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Montella, Maurizio" sort="Montella, Maurizio" uniqKey="Montella M" first="Maurizio" last="Montella">Maurizio Montella</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Epidemiology and Biostatistics, National Cancer Institute - IRCCS- G. Pascale Foundation, Via M. Semmola, 80131, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Epidemiology and Biostatistics, National Cancer Institute - IRCCS- G. Pascale Foundation, Via M. Semmola, 80131, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="La Vecchia, Carlo" sort="La Vecchia, Carlo" uniqKey="La Vecchia C" first="Carlo" last="La Vecchia">Carlo La Vecchia</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Rossi, Marta" sort="Rossi, Marta" uniqKey="Rossi M" first="Marta" last="Rossi">Marta Rossi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy. marta.rossi@unimi.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author></analytic><series><title level="j">Cancer causes & control : CCC</title><idno type="eISSN">1573-7225</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antioxidants (administration & dosage)</term><term>Body Mass Index</term><term>Case-Control Studies</term><term>Diet</term><term>Energy Intake</term><term>Female</term><term>Humans</term><term>Italy (epidemiology)</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Neoplasm Grading</term><term>Odds Ratio</term><term>Proanthocyanidins (administration & dosage)</term><term>Prostatic Neoplasms (epidemiology)</term><term>Risk Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse multivariée</term><term>Antioxydants (administration et posologie)</term><term>Facteurs de risque</term><term>Femelle</term><term>Grading des tumeurs</term><term>Humains</term><term>Indice de masse corporelle</term><term>Italie (épidémiologie)</term><term>Modèles logistiques</term><term>Mâle</term><term>Odds ratio</term><term>Proanthocyanidines (administration et posologie)</term><term>Ration calorique</term><term>Régime alimentaire</term><term>Sujet âgé</term><term>Tumeurs de la prostate (épidémiologie)</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antioxidants</term><term>Proanthocyanidins</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Italy</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antioxydants</term><term>Proanthocyanidines</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Prostatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Italie</term><term>Tumeurs de la prostate</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Body Mass Index</term><term>Case-Control Studies</term><term>Diet</term><term>Energy Intake</term><term>Female</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Neoplasm Grading</term><term>Odds Ratio</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse multivariée</term><term>Facteurs de risque</term><term>Femelle</term><term>Grading des tumeurs</term><term>Humains</term><term>Indice de masse corporelle</term><term>Modèles logistiques</term><term>Mâle</term><term>Odds ratio</term><term>Ration calorique</term><term>Régime alimentaire</term><term>Sujet âgé</term><term>Études cas-témoins</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Italie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Proanthocyanidins are polymers of monomeric unit flavan-3-ols with antioxidant, anti-inflammatory and free radical scavenging activities. We investigated the association between proanthocyanidin intake and prostate cancer risk through data that were collected between 1991 and 2002 in an Italian case-control study, including a total of 1,294 incident, histologically confirmed cases of prostate cancer and 1,451 controls admitted to hospital for acute, non-neoplastic, and non-hormone-related diseases. We estimated odds ratios (ORs) and their 95% confidence intervals (CIs) using multiple logistic regression models, and computed energy-adjusted proanthocyanidin intakes using the residual method. The ORs for the highest versus the lowest tertile were 0.80 (95% CI 0.83-1.00) for energy-adjusted monomers and dimers combined, 0.72 (95% CI 0.59-0.87) for polymers with ≥ 3 mers, and 0.72 (95% CI 0.59-0.88) for total proanthocyanidins. The inverse relation was stronger among cases with a Gleason score ≥ 7, with the ORs of 0.56 (95% CI 0.40-0.78) for monomers and dimers, 0.62 (95% CI 0.40-0.78) for polymers with ≥ 3 mers, and 0.57 (95% CI 0.42-0.77) for total proanthocyanidins. These risk estimates were consistent across strata of age, education, body mass index, and family history of prostate cancer. Our data indicate an inverse association between proanthocyanidins and prostate cancer risk.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Lombardie</li></region><settlement><li>Milan</li></settlement></list><tree><country name="Italie"><region name="Lombardie"><name sortKey="Praud, Delphine" sort="Praud, Delphine" uniqKey="Praud D" first="Delphine" last="Praud">Delphine Praud</name></region><name sortKey="Bosetti, Cristina" sort="Bosetti, Cristina" uniqKey="Bosetti C" first="Cristina" last="Bosetti">Cristina Bosetti</name><name sortKey="Facchini, Gaetano" sort="Facchini, Gaetano" uniqKey="Facchini G" first="Gaetano" last="Facchini">Gaetano Facchini</name><name sortKey="Guercio, Valentina" sort="Guercio, Valentina" uniqKey="Guercio V" first="Valentina" last="Guercio">Valentina Guercio</name><name sortKey="La Vecchia, Carlo" sort="La Vecchia, Carlo" uniqKey="La Vecchia C" first="Carlo" last="La Vecchia">Carlo La Vecchia</name><name sortKey="Montella, Maurizio" sort="Montella, Maurizio" uniqKey="Montella M" first="Maurizio" last="Montella">Maurizio Montella</name><name sortKey="Parpinel, Maria" sort="Parpinel, Maria" uniqKey="Parpinel M" first="Maria" last="Parpinel">Maria Parpinel</name><name sortKey="Rossi, Marta" sort="Rossi, Marta" uniqKey="Rossi M" first="Marta" last="Rossi">Marta Rossi</name><name sortKey="Serraino, Diego" sort="Serraino, Diego" uniqKey="Serraino D" first="Diego" last="Serraino">Diego Serraino</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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